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. Author manuscript; available in PMC: 2017 Jun 16.
Published in final edited form as: J Med Chem. 2016 Apr 21;59(10):4511–4525. doi: 10.1021/acs.jmedchem.5b01762

Scheme 8. Synthesis of Analogues 15a–ba.

Scheme 8

aReagents and conditions: (a) allyl bromide, Cs2CO3, DMF, microwave, 80 °C, 30 min, 58%; (b) FCH2CH2OH, DEAD, Ph3P, THF, microwave, 60 °C, 40 min; (c) H2, Pd/C, MeOH, overnight, 36–45%.