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. Author manuscript; available in PMC: 2017 Jun 16.
Published in final edited form as: J Med Chem. 2016 Apr 21;59(10):4511–4525. doi: 10.1021/acs.jmedchem.5b01762

Table 1.

RAD51 D-Loop Inhibitory and RAD51-ssDNA Binding Stimulatory/Inhibitory Activities of 1, 7, and 8a

compd D-loops
ssDNA binding
max inhibition effect (%) IC50 (μM) max effect (%) IC50 (μM)
1 74 ± 2 21.3 ± 7.8 33 ± 10↓ >100
7 17 ± 3 >100 47 ± 33↑ Stim
8 67 ± 11 13.0 ± 4.7 40 ± 28↑ Stim
a

↑:Indicates that the compound stimulates RAD51-ssDNA binding. ↓:Compound inhibits RAD51-ssDNA binding. Stim: Compound is a stimulator.