Table 2. Parameters of the chemotherapy-induced myelosuppression model of Friberg et al. [ 10, Table 4].
Circ 0: baseline neutrophil concentration; MTT : mean transit time between the 5 model compartments; γ: exponent of feedback loop; EC 50, E max: parameters of a model (of the standard E max type) governing docetaxel-induced depletion in the proliferative compartment.
Param | Units | Mean | CV |
---|---|---|---|
Circ 0 | cells/mm 3 | 5050 | 0.42 |
MTT | hours | 89.3 | 0.16 |
γ | - | 0.163 | 0.039 |
E max | µM | 83.9 | 0.33 |
EC 50 | µM | 7.17 | 0.50 |