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. 2017 Feb 7;6:112. [Version 1] doi: 10.12688/f1000research.10624.1

Table 2. Parameters of the chemotherapy-induced myelosuppression model of Friberg et al. [ 10, Table 4].

Circ 0: baseline neutrophil concentration; MTT : mean transit time between the 5 model compartments; γ: exponent of feedback loop; EC 50, E max: parameters of a model (of the standard E max type) governing docetaxel-induced depletion in the proliferative compartment.

Param Units Mean CV
Circ 0 cells/mm 3 5050 0.42
MTT hours 89.3 0.16
γ - 0.163 0.039
E max µM 83.9 0.33
EC 50 µM 7.17 0.50