Table 7. Mental and neurological outcomes for individual drugs for prophylaxis studies.
- No observations.
| Drug | Psychiatric/
behavioural |
Mild
neurological perturbations |
Motor
problems |
Sleep
pattern disturbances |
Personality
changes |
Seizures | Headache | Hearing &
balance problems |
Visual
problems |
Cognition
problems |
|---|---|---|---|---|---|---|---|---|---|---|
|
Atovaquone,
N=2670 (%) |
819 (30.67) | 54 (2.02) | - | 179 (6.70) | - | - | 51 (1.91) | - | 24 (0.90) | - |
|
Mefloquine,
N=197959 (%) |
8146 (4.11) | 28699 (14.50) | - | 23630 (11.94) | 9 (0.00) | - | 30697 (15.51) | 4 (0.00) | 14321 (7.235) | 53 (0.03) |
|
Primaquine,
N=155 (%) |
1 (0.65) | - | - | - | - | - | - | - | - | |
|
Pyrimethamine,
N=140773 (%) |
6600 (4.69) | 28094 (19.96) | - | 23280 (16.54) | - | - | 30593
(21.73) |
- | 14297
(10.16) |
- |
|
Chloroquine,
N=180314 (%) |
7985 (4.43) | 28140 (15.61) | - | 22456 (12.45) | - | - | 30593
(16.97) |
- | 14297
(7.93) |
25 (0.01) |
|
Proguanil,
N=180571 (%) |
8060 (4.46) | 28194 (15.61) | - | 22635 (12.54) | - | - | 30644
(16.97) |
- | 14321
(7.93) |
25 (0.01) |
|
Sulfadoxine,
N=1609 (%) |
1 (0.06) | - | - | 885 (55.00) | - | - | - | - | - | - |
|
Quinine, N=160
(%) |
1(0.63) | - | - | - | - | - | - | - | - | - |
|
Dapsone,
N=155 (%) |
1 (0.65) | - | - | - | - | - | - | - | - | - |
|
Doxycycline,
N=36077 (%) |
578 (1.60) | - | - | 8 (0.02) | - | - | - | - | - | - |
|
Quinidine,
N=31(%) |
- | 5 (16.13) | - | 3 (9.68) | - | - | 4 (12.90) | 1 (3.23) | - | - |
|
Minocycline,
N=120 (%) |
- | - | - | - | 58 (48.33) | - | 44 (36.67) | 6 (5.00) | - | 48 (40.00) |