Table III.
Systolic blood pressure and 5HTTLPR genotype by population group
| Group | Genotype
|
Additive model
|
Dominant model
|
||||
|---|---|---|---|---|---|---|---|
| L’L’ | L’S’ | S’S’ | Regression estimate (mm Hg) | P | Regression estimate (mm Hg) | P | |
| Add Health Sample | |||||||
| White | 126.11 (125.12,127.10) | 126.16 (125.27,127.05) | 125.23 (124.24,126.23) | 0.44 (0.04,0.84) | .032 | 0.91 (0.26,1.56) | .006 |
| African American | 129.51 (127.73,131.29) | 128.93 (127.25,130.61) | 130.40 (128.53,132.26) | −0.39 (−1.13,0.36) | .311 | −1.27 (−2.53, −0.01) | .048 |
| Hispanic/Latino | 125.77 (123.49,128.05) | 126.96 (124.90,129.01) | 126.69 (124.60,128.79) | −0.34 (−1.10, 0.42) | .379 | 1.07 (−0.34, 2.48) | .135 |
| Asian/Pacific Islander | 127.88 (122.46,133.29) | 129.65 (126.19,133.12) | 129.73 (126.34,133.11) | −0.38 (−1.84,1.09) | .614 | −0.23 (−1.91, 1.46) | .791 |
| Native American | 129.68 (124.22,135.15) | 126.90 (122.40,131.40) | 133.87 (128.60,139.13) | −2.16 (−4.40,0.75) | .058 | −6.05 (−9.59, −2.51) | .001 |
| Singapore sample | |||||||
| Chinese | 130.73 (127.13,134.33) | 134.21 (132.88,135.54) | 134.26 (133.32,135.21) | 0.67 (−0.49, 1.83) | .259 | 3.52 (−0.02, 7.12) | .055 |
| Indian | 134.93 (129.99,139.88) | 139.77 (137.34,142.20) | 138.55 (136.48,140.61) | 0.50 (−1.62, 2.62) | .646 | 4.10 (−0.94, 9.13) | .111 |
| Malay | 139.78 (134.90,144.66) | 139.75 (137.56,141.93) | 140.84 (138.95,142.73) | 0.82 (−1.10, 2.74) | .403 | −1.09 (−3.45, 1.27) | .364 |
| All Asians combined (Singapore sample only) | 133.38 (130.90,135.85) | 136.30 (135.23,137.37) | 136.41 (135.52,137.30) | 0.72 (−0.18, 1.62) | .117 | 2.99 (0.51, 5.48) | .018 |
Values in row with group name are point estimates. Values in parentheses in second row of each group are 95% confidence intervals.
For Add Health sample, estimates are derived from a mixed model adjusting for age, BMI, gender, and antihypertensive medication use, incorporating sample design parameters.
Estimates for the Singapore sample are derived from a general linear model with the same covariates used in the Add Health sample.
Additive models test for linear trend across 0, 1, or 2 copies of L’. Dominant model for White, Black, Asian/Pacific Islander, Native America, and Malay compares L’ carriers to S’ homozygotes. Dominant model for Hispanic/Latino, Chinese, and Indian compares S’ carriers to L’ homozygotes. Dominant Model for all Asians Combined in Singapore sample compares S’ Carriers to L’ homozygotes.