Table IV.
Diastolic blood pressure and 5HTTLPR genotype by population group
| Group | Genotype
|
Additive model
|
Dominant model
|
||||
|---|---|---|---|---|---|---|---|
| L’L’ | L’S’ | S’S’ | Regression estimate (95%CL) | P | Regression estimate (95%CL) | P | |
| Add Health sample | |||||||
| White | 80.22 (79.45,81.00) | 80.56 (79.87,81.26) | 80.32 (79.54,81.10) | −0.05 (−0.37, 0.27) | .771 | 0.13 (−0.39,0.69) | .615 |
| African American | 81.32 (79.91,82.72) | 82.36 (81.04,83.69) | 83.13 (81.67,84.60) | −0.92 (−1.49, −0.35) | .002 | −1.13 (−2.09, −0.16) | .022 |
| Hispanic/Latino | 79.88 (78.05,81.72) | 80.49 (78.83,82.14) | 80.84 (79.16,82.53) | −0.46 (−1.06, 0.15) | .138 | −0.52 (−1.42, 0.37) | .188 |
| Asian/Pacific Islander | 81.08 (76.71,85.46) | 82.59 (79.91,85.27) | 84.23 (81.61,86.86) | −1.62 (−2.83, −0.41) | .009 | −1.77 (−3.16, −0.38) | .012 |
| Native American | 84.33 (79.74,88.91) | 80.47 (76.69,84.25) | 84.61 (80.19,89.03) | −0.20 (−2.08, 1.67) | .831 | −2.86 (−5.86, 0.14) | .061 |
| Singapore Sample | |||||||
| Chinese | 76.04 (73.95,78.13) | 78.71 (77.94,79.48) | 78.41 (77.87,78.96) | 0.23 (−0.44, 0.90) | .498 | 2.46 (0.37, 4.54) | .021 |
| Indian | 78.95 (76.28,81.62) | 80.42 (79.11,81.73) | 80.39 (79.28,81.51) | 0.40 (−0.75, 1.54) | .496 | 1.45 (−1.26, 4.21) | .293 |
| Malay | 79.94 (77.12,82.76) | 80.18 (78.91,81.44) | 81.53 (80.44,82.63) | 1.08 (−0.03, 2.19) | .056 | −1.39 (−2.75, −0.03) | .046 |
| All Asians Combined (Singapore sample only) | 77.42 (76.01,78.84) | 79.26 (78.65,79.87) | 79.34 (78.83,79.85) | 0.46 (−0.06, 0.97) | .081 | 1.89 (0.47, 3.31) | .009 |
Values in row with group name are point estimates. Values in parentheses in second row of each group are 95% confidence intervals.
For Add Health sample, estimates are derived from a mixed model adjusting for age, BMI, gender, and antihypertensive medication use, incorporating sample design parameters.
Estimates for the Singapore sample are derived from a general linear model with the same covariates used in the Add Health sample.
Additive models test for linear trend across 0, 1, or 2 copies of L’. Dominant model for White, Black, Asian/Pacific Islander, Native America, and Malay compares L’ carriers to S’ homozygotes. Dominant model for Hispanic/Latino, Chinese, and Indian compares S’ carriers to L’ homozygotes. Dominant Model for all Asians Combined in Singapore sample compares S’ Carriers to L’ homozygotes.