Table V.

Odds of increased severity of hypertension stage by triallelic 5HTTLPR genotype and population group

Group	Odds ratio		P
	Additive	Dominant	Additive	Dominant
Add Health sample
White	1.11a (1.04–1.19)b	1.23 (1.10–1.38)	.003	.0003
African American	0.85 (0.76–0.96)	0.78 (0.65–0.94)	.006	.010
Hispanic	1.06 (0.92–1.21)	0.97 (0.75–1.26)	.429	.838
Asian/Pacific Islander	0.71 (0.53–0.96)	0.68 (0.48–0.96)	.024	.029
Native American	0.73 (0.41–1.29)	0.34 (0.13–0.89)	.276	.028
Singapore sample
Chinese	1.09 (0.95–1.25)	1.51 (0.97–2.35)	.218	.067
Indian	1.023 (0.829–1.275)	1.17 (0.70–1.96)	.803	.548
Malay	1.11 (0.90–1.37)	0.87 (0.67–1.13)	.346	.301
All Asians Combined (Singapore sample only)	1.09 (0.98–1.20)	1.38 (0.98–1.72)	.052	.068

Estimates are derived from a cumulative logistic regression model predicting hypertension status adjusting for age, BMI, gender, and antihypertensive medication, with sample design parameters for the Add Health sample as described earlier. Hypertension status was modeled as 4 ordered categories: Normal, Prehypertension, Stage I Hypertension, and Stage 2 Hypertension.

Additive models test for linear trend across 0, 1, or 2 copies of L’. Dominant model for White, Black, Asian/Pacific Islander, Native America, and Malay compares L’ carriers to S’ homozygotes. Dominant model for Hispanic/Latino, Chinese and Indian compares S’ carriers to L’ homozygotes. Dominant Model for All Asians Combined in Singapore sample compares S’ Carriers to L’ homozygotes.

^aWithin-group mean.

^b95% Confidence Interval.