Skip to main content
. 2017 Jul 18;6:724. Originally published 2017 May 18. [Version 2] doi: 10.12688/f1000research.11561.2

Figure 6. GTP channeling, the dynamins and the NM23/NDPK connection.

Figure 6.

a: Classical endocytic dynamins (dynamin-1 and dynamin-2) are recruited to clathrin-coated pits where they catalyse plasma membrane fission by creating torque. b: NM23, an NDPK that produces GTP from GDP and ATP, is a hexamer with six active sites. c: The NDPKs NM23-H1 and NM23-H2 (green) are recruited to clathrin-coated pits by their physical interaction with dynamin-1 and dynamin-2 (red). The NDPKs thus regenerate local GTP from GDP and intracellular ATP by a channeling mechanism to optimise dynamin activity. d: NM23-H4 activity in the mitochondrial intermembrane space uses the ATP from oxidative phosphorylation to regenerate GTP directly for fusion of the IMM by OPA1. PM, plama membrane; GTP, guanosine 5’-triphosphate; GDP, guanosine diphosphate; ADP, adenosine diphosphate; ATP, adenosine 5’-triphosphate; P i, inorganic phosphate; ANT, adenine nucleotide transporter; IMM, inner mitochondrial membrane; OPA1, optic atrophy 1; NDPK, nucleoside diphosphate kinases.