Extended Data Figure 7. Effect of KDU731 on severity of diarrhoea and dehydration in the neonatal calf model of cryptosporidiosis.
Severity of diarrhoea and dehydration in individual calves challenged with 5 × 107 C. parvum oocysts. Infected calves were treated with vehicle (n = 6) or with KDU731 (n = 7); n represents the number of calves. Every 12 h, calves were stimulated to defecate, faecal consistency was evaluated, and hydration status was assessed. Faecal consistency and hydration scores were assigned according to the study rubric (see Supplementary Information). The schematic representation shows the faecal consistency (a) and hydration scores (b) throughout the drug treatment period. Faecal consistency and hydration began to improve within 48 h of initiating treatment with KDU731.