Table 1.
Single locus analyses for association of PAC1 gene polymorphisms and problematic alcohol use
| SNP | HWE P-value | Subjects – N (%) | Model | Means and SDs for genotype groups | Statistics |
|---|---|---|---|---|---|
| rs1157655 | 0.45 | TT: 24 (4.9), GT: 185 (37.7), GG: 282 (57.4) | Dominant | not GG: M =7.11, SD =4.68; GG: M =6.98, SD =4.54 |
F=0.11; P=0.74573 |
| rs7784067 | 1 | CC: 91 (18.5), CT: 242 (49.3), TT: 158 (32.2) | Dominant | not TT: M =6.89, SD =4.52; TT: M =7.33, SD =4.76 |
F=1.11; P=0.87917 |
| Recessive | CC: M =6.99, SD =5.02; not CC: M =7.05, SD =4.50 |
F=0.02; P=1 |
|||
| Multiplicative | CT: M =6.86, SD =4.32; not CT: M =7.20, SD =4.85 |
F=0.74; P=1 |
|||
| rs35413074 | 0.18 | CC: 24 (4.9), AC: 195 (39.8), AA: 271 (55.3) | Dominant | not AA: M =6.78, SD =4.63; AA: M =7.25, SD =4.58 |
F=1.20; P=0.27435 |
| rs10241138 | 1 | CC: 5 (1.0), CT: 92 (18.7), TT: 394 (80.2) | Dominant | not TT: M =7.69, SD =5.25; TT: M =6.87, SD =4.41 |
F=2.57; P=0.10981 |
| rs10226318 | 0.28 | GG: 65 (13.2), GT: 244 (49.7), TT: 182 (37.1) | Dominant | not TT: M =6.92, SD =4.71; TT: M =7.24, SD =4.40 |
F=0.52; P=1 |
| Recessive | GG: M =7.11, SD =4.82; not GG: M =7.02, SD =4.57 |
F=0.04; P=1 |
|||
| Multiplicative | GT: M =6.86, SD =4.69; not GT: M =7.2, SD =4.51 |
F=0.70; P=1 |
|||
| rs17723231 | 0.39 | TT: 43 (8.8), CT: 220 (44.8), CC: 228 (46.4) | Dominant | not CC: M =6.86, SD =4.67; CC: M =7.24, SD =4.51 |
F=0.86; P=1 |
| Recessive | TT: M =7.07, SD =4.93; not TT: M =7.03, SD =4.57 |
F=0.01; P=1 |
|||
| Multiplicative | CT: M =6.82, SD =4.63; not CT: M =7.21, SD =4.57 |
F=0.95; P=0.99255 |
|||
| rs1006622 | 0.59 | CC: 106 (21.6), CT: 237 (48.3), TT: 148 (30.1) | Dominant | not TT: M =6.89, SD =4.72; TT: M =7.36, SD =4.30 |
F=1.15; P=0.85196 |
| Recessive | CC: M =7.28, SD =5.14; not CC: M =6.97, SD =4.44 |
F=0.39; P=1 |
|||
| Multiplicative | CT: M =6.72, SD =4.52; not CT: M =7.33, SD =4.66 |
F=2.27; P=0.39669 |
|||
| rs12533865 | 0.99 | CC: 2 (0.4), CT: 53 (10.8), TT: 436 (88.8) | Dominant | not TT: M =7.11, SD =5.21; TT: M =7.03, SD =4.52 |
F=0.05; P=0.82552 |
| rs887703 | 0.19 | GG: 53 (10.8), AG: 238 (48.5), AA: 200 (40.7) | Dominant | not AA: M =6.66, SD =4.51; AA: M =7.58, SD =4.67 |
F=4.72; P=0.09082 |
| Recessive | GG: M =8.15, SD =5.44; not GG: M =6.90, SD =4.47 |
F=3.12; P=0.23466 |
|||
| Multiplicative | AG: M =6.33, SD =4.22; not AG: M =7.7, SD =4.84 |
F=10.58; P=0.00367 |
|||
| rs12668955 | 0.23 | AA: 126 (25.7), AG: 231 (47.1), GG: 133 (27.1) | Dominant | not GG: M =7.24, SD =4.51; GG: M =6.48, SD =4.80 |
F=2.58; P=0.32649 |
| Recessive | AA: M =7.71, SD =4.81; not AA: M =6.79, SD =4.51 |
F=3.66; P=0.16882 |
|||
| Multiplicative | AG: M =6.97, SD =4.34; not AG: M =7.08, SD =4.83 |
F=0.06; P=1 |
|||
| rs2302475 | 0.56 | CC: 103 (21.0), CT: 252 (51.3), TT: 136 (27.7) | Dominant | not TT: M =6.9, SD =4.44; TT: M =7.39, SD =4.97 |
F=0.93; P=1 |
| Recessive | CC: M =5.53, SD =4.25; not CC: M =7.43, SD =4.61 |
F=14.47; P=0.00048 |
|||
| Multiplicative | CT: M =7.46, SD =4.41; not CT: M =6.59, SD =4.75 |
F=4.87; P=0.08356 |
|||
| rs1541516 | 0.95 | AA: 3 (0.6), AG: 80 (16.3), GG: 408 (83.1) | Dominant | not GG: M =7.84, SD =5.40; GG: M =6.87, SD =4.41 |
F=3.01; P=0.08322 |
| rs2267733 | 0.34 | TT: 71 (14.5), CT: 246 (50.1), CC: 174 (35.4) | Dominant | not CC: M =7.30, SD =4.32; CC: M =6.56, SD =5.04 |
F=3.11; P=0.23599 |
| Recessive | TT: M =7.07, SD =4.32; not TT: M =7.03, SD =4.65 |
F=0.01; P=1 |
|||
| Multiplicative | CT: M =7.36, SD =4.33; not CT: M =6.71, SD =4.84 |
F=2.87; P=0.27219 |
|||
| rs2267738 | 0.9 | AA: 22 (4.5), AG: 169 (34.4), GG: 300 (61.1) | Dominant | not GG: M =7.32, SD =4.51; GG: M =6.85, SD =4.65 |
F=1.14; P=0.28578 |
| rs2267740 | 0.85 | TT: 8 (1.6), CT: 118 (24.0), CC: 365 (74.3) | Dominant | not CC: M =7.39, SD =4.19; CC: M =6.91, SD =4.73 |
F=1.01; P=0.31479 |
| rs4723047 | 0.86 | CC: 24 (4.9), CG: 175 (35.6), GG: 292 (59.5) | Dominant | not GG: M =7.00, SD =4.65; GG: M =7.06, SD =4.57 |
F=0.03; P=0.87311 |
| rs4503014 | 1 | GG: 33 (6.7), AG: 188 (38.3), AA: 270 (55.0) | Dominant | not AA: M =6.69, SD =4.42; AA: M =7.31, SD =4.72 |
F=2.30; P=0.39121 |
| Recessive | GG: M =5.58, SD =3.04; not GG: M =7.14, SD =4.67 |
F=3.58; P=0.17700 |
|||
| Multiplicative | AG: M =6.89, SD =4.60; not AG: M =7.13, SD =4.60 |
F=0.33; P=1 |
Notes: Percentages are based on the number of all subjects included in the analysis (N=491). Percentages not summing up to 100 are due to rounding. Statistics are based on analysis of covariance (ANCOVA) model including age as a covariate. All supplied means and SDs are descriptive and not least-square estimates.
Abbreviations: SNP, single nucleotide polymorphism; HWE, Hardy–Weinberg equilibrium; SD, standard deviation.