Figure 1.
(A) Experimental model schema: at 16 weeks (when the diabetic parameters were developed), some GK rats were injected with sitagliptin (10 mg·kg−1 per day) until sacrifice at 9 months. (B) Kidney Masson’s trichrome and PAS staining: significant glomerulosclerosis and interstitial fibrosis (black arrow) are observed in GK kidney vs. Wistar and Sita group (Kimmelstiel–Wilson nodule, red arrow), and PAS staining shows focal tubular dilation (green arrow).
Abbreviations: GK, Goto-Kakizaki; PAS, Periodic Acid Schiff.