Table 4.
Factors associated with treatment outcome of TB in TB/HIV co-infected patients at MTUTH, September 2012 to December 2015
| Variables | Treatment success rate
|
Univariate analysis
|
Multivariable analysis
|
||||
|---|---|---|---|---|---|---|---|
| Unsuccessful | Successful | p-value | COR (95%CI) | p-value | AOR (95%CI) | ||
| Sex | Male | 69 | 28 | 1.00 | 1.00 | ||
| Female | 62 | 29 | 0.66 | 0.87 (0.47, 1.62) | |||
| Age group | 15–29 | 67 | 24 | 1.00 | 1.00 | ||
| 30–44 | 57 | 29 | 0.29 | 0.70 (0.37, 1.34) | |||
| 45–59 | 5 | 4 | 0.26 | 0.448 (0.11, 1.81) | |||
| ≥60 | 2 | 0 | 0.99 | 546410616 (0.00, –) | |||
| Education | Illiterate | 34 | 18 | 0.30 | 0.31 (0.04, 2.82) | ||
| Primary | 50 | 20 | 0.43 | 0.42 (0.05, 3.68) | |||
| Secondary | 41 | 18 | 0.39 | 0.38 (0.04, 3.37) | |||
| College | 6 | 1 | 1.00 | 1.00 | |||
| Marital status | Single | 50 | 17 | 1.00 | 1.00 | 1.00 | 1.00 |
| Married | 43 | 22 | 0.29 | 0.66 (0.31, 1.41) | 0.14 | 0.54 (0.24, 1.22) | |
| Widowed | 20 | 7 | 0.96 | 0.97 (0.35, 2.70) | 0.96 | 0.97 (0.332, 2.84) | |
| Divorced | 18 | 11 | 0.22 | 0.56 (0.22, 1.41) | 0.27 | 0.57 (0.21, 1.55) | |
| Smear status | Positive | 25 | 18 | 0.06 | 0.51 (0.25, 1.04) | 0.02 | 0.40 (0.18, 0.88) |
| Negative | 106 | 39 | 1.00 | 1.00 | 1.00 | 1.00 | |
| TB type | SNPTB | 86 | 32 | 1.00 | 1.00 | 1.00 | 1.00 |
| SPPTB | 25 | 18 | 0.08 | 0.52 (0.25, 1.07) | 0.02 | 0.40 (0.18, 0.88) | |
| EPTB | 20 | 7 | 0.90 | 1.06 (0.41, 2.75) | 0.70 | 0.82 (0.30, 2.27) | |
| WHO stage at TB Dx | III | 98 | 46 | 1.00 | 1.00 | ||
| IV | 33 | 11 | 0.38 | 1.41 (0.65, 3.03) | |||
| Initial WHO stage | II | 16 | 16 | 1.00 | 1.00 | 1.00 | 1.00 |
| III | 91 | 35 | 0.02 | 2.60 (1.17, 5.76) | 0.03 | 3.08 (1.14, 8.38) | |
| IV | 24 | 6 | 0.02 | 4.00 (1.29, 12.42) | 0.02 | 5.80 (1.36, 24.71) | |
| Duration of RVI at TB Dx in years | <1 | 93 | 34 | 1.00 | 1.00 | 1.00 | 1.00 |
| 1–5 | 32 | 16 | 0.39 | 0.73 (0.36, 1.50) | 0.66 | 1.23 (0.49, 3.07) | |
| >5 | 6 | 7 | 0.05 | 0.31 (0.10, 0.99) | 0.34 | 0.52 (0.14, 2.00) | |
| CD4 count at ART initiation | <200 | 54 | 18 | 1.00 | 1.00 | 1.00 | 1.00 |
| 200–350 | 50 | 21 | 0.54 | 0.79 (0.38, 1.66) | 0.87 | 1.07 (0.47, 2.42) | |
| >350 | 27 | 18 | 0.09 | 0.50 (0.22, 1.11) | 0.79 | 0.88 (0.35, 2.25) | |
| ART changed | Yes | 20 | 16 | 1.00 | 1.00 | 1.00 | 1.00 |
| No | 111 | 41 | 0.04 | 2.17 (1.02, 4.58) | 0.31 | 1.62 (0.635, 4.12) | |
| CD4 count at TB Dx | <350 | 118 | 49 | 1.00 | 1.00 | ||
| 350–500 | 12 | 7 | 0.50 | 0.71 (0.26, 1.92) | |||
| >500 | 1 | 1 | 0.54 | 0.42 (0.02, 6.77) | |||
Abbreviations: ART, anti-retroviral therapy; Dx; diagnosis; EPTB, extrapulmonary tuberculosis; MTUTH, Mizan-Tepi University Teaching Hospital; RVI, retroviral infection; SNPTB, smear negative pulmonary tuberculosis; SPPTB, smear positive pulmonary tuberculosis; TB, tuberculosis; WHO, World Health Organization.