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Neuronal cells are selectively vulnerable to TRAIL. (A) TRAIL induces cell death in N2a cells at 5 μg/ml and 10 μg/ml. F3,28 = 9.197, p = 0.0002. Bonferroni post hoc p = 0.057 at 1 μg/ml, p = 0.0065 μg/ml, p = 0.0001 at 10 μg/ml. TRAIL did not affect cell viability in (B) BV2 (F3,28 = 1.902, p = 0.152) or (C) Sol8 cells (F3,28 = 2.718, p = 0.063).
