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. 2017 Mar 27;1(2):122–139. doi: 10.1002/hep4.1030

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© 2017 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Association of ER stress with Golgi dysfunction in primary mouse hepatocytes. (A) Induction of sXBP1 in PMH treated with anti‐HIV drugs and alcohol. RL10, RL at 10 μg/mL; RL20, RL at 20 μg/mL. (B) Golgi fragmentation in PMH treated with RL. Left panel, confocal images (×630) showing Golgi fragmentation (indicated by GM130 labeled with green fluorescence) in PMH treated with the drug for 2 hours and 4 hours. (C) Quantitation of drug‐induced Golgi fragmentation at different time points and concentrations. Error bars indicate standard error mean (SEM). Abbreviation: DMSO, dimethyl sulfoxide; uXBP1, un‐spliced XBP1.