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. 2017 Mar 27;1(2):122–139. doi: 10.1002/hep4.1030

Figure 5.

Figure 5

Association of drug‐induced Golgi fragmentation with the onset of the ER stress response. (A) Confocal images showing the time point of Golgi enzyme dislocation/redistribution revealed by immunofluorescent staining with anti‐MAN2A1 antibodies. (B) Onset of the ER stress response indicated by expression changes of CHOP and GRP78 measured with qPCR. (C) Inhibition of RL‐induced MAN2A1 dislocation by a PKA inhibitor, H89 (×630). (D) Inhibition of the drug‐induced ER stress by H89. **** P < 0.0001 compared to control or indicated otherwise; n = 4‐5. Error bars indicate standard error mean (SEM). Abbreviation: PKA, protein kinase A.