. Author manuscript; available in PMC: 2018 May 30.

Published in final edited form as: Eur J Pharm Sci. 2017 Mar 3;103:85–93. doi: 10.1016/j.ejps.2017.03.003

Table 3.

Pharmacokinetic parameters of mPEG-DSPE HSPC and mPEG-DSPE C8Chems cis-platinum containing liposomes based upon the circulating platinum levels in healthy mice.

PK parameters	HSPC	C8Chems
t_{1/2, α (hr)}	1.3	–
t_{1/2, β (hr)}	36.8	20.7
V₁ (g blood)	0.77	1.2
AUC_{0 → ∞} (%ID ∗ h/g blood)	1456	902
k_el (1/min)	0.0005	0.0006

mg/kg in healthy mice.