Table 2.
PiB-PET and postmortem pathologic assessment in patients with FTD
| Number | Clin dx | MI | Path dx | M/F | Age at death (years) | Age at onset (years) | Death duration (years) | Mut | SUVRCb | PiB stat | TL (years) | Amyloid β A score [7] | Braak NFT score [7] | CERAD neuritic score [7] | ABC score [7] |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | nfv-PPA | No | FTD-tau | M | 53 | 47 | 6 | 0 | 1.03 | Low | 6 | 0 | 0 | 0 | 0 |
| 2 | sv-PPA | MND | FTD-TDP | M | 62 | 62 | 0 | 0 | 1.02 | Low | 1 | 0 | 0 | 0 | 0 |
| 3 | bvFTD | No | FTD-TDP | M | 64 | 59 | 5 | GRN | 0.99 | Low | 3 | 1 | 0 | 0 | 1 |
| 4 | bvFTD | No | FTD-TDP | F | 68 | 64 | 4 | GRN | 0.88 | Low | 4 | 0 | 0 | 0 | 0 |
| 5 | nfv-PPA | EPS | FTD-tau | M | 69 | 65 | 4 | 0 | 1.04 | Low | 3 | 0 | 2 | 0 | 1 |
| 6 | nfv-PPA | No | FTD-tau | F | 72 | 71 | 1 | 0 | 0.97 | Low | 1 | 0 | 1 | 0 | 1 |
| 7 | sv-PPA | No | FTD-tau | F | 73 | 67 | 6 | 0 | 0.99 | Low | 4 | 0 | 0 | 0 | 0 |
| 8 | nfv-PPA | EPS | FTD-tau | M | 73 | 71 | 2 | 0 | 1.18 | Low | 2 | 0 | 0 | 0 | 0 |
| 9 | CBS | No | FTD-tau | F | 74 | 69 | 5 | 0 | 1.06 | Low | 4 | 0 | 0 | 0 | 0 |
| 10 | nfv-PPA | No | FTD-tau | F | 76 | 72 | 4 | 0 | 1.02 | Low | 3 | 2 | 1 | 0 | 1 |
| 11 | nfv-PPA | No | FTD-tau | M | 82 | 78 | 4 | 0 | 1.57 | High | 4 | 3 | 1 | 2 | 1 |
| 12 | lv-PPA | No | AD | F | 73 | 67 | 6 | 0 | 1.25 | Low | 6 | 3 | 3 | 3 | 3 |
| 13 | nfv-PPA | No | AD | M | 74 | 70 | 4 | 0 | 2.30 | High | 3 | 3 | 3 | 3 | 3 |
| 14 | lv-PPA | No | AD | M | 72 | 68 | 4 | 0 | 1.68 | High | 2 | 3 | 3 | 3 | 3 |
| 15 | CBS | No | AD | F | 64 | 59 | 5 | 0 | 1.56 | High | 4 | 3 | 3 | 3 | 3 |
Abbreviations: AD, Alzheimer's disease; CBD, corticobasal degeneration; CBS, corticobasal syndrome; Clin dx, clinical diagnosis; CERAD, Consortium to Establish a Registry for Alzheimer's Disease; EPS, extrapyramidal syndrome; F, female; lv-PPA, logopenic variant primary progressive aphasia; M, male; MI, motor impairment; MND, motor neuron disease; Mut, mutation; N/A, Not available; NFT, neurofibrillary tangle; nfv-PPA, non-fluent primary progressive aphasia; Path dx, pathological diagnosis; PiB stat, 11C-Pittsburgh compound B status; PiD, Pick's disease; PSP, progressive supranuclear palsy; SUVRCb, standardized uptake value ratio; sv-PPA, semantic variant primary progressive aphasia; TDP, transactive response DNA binding protein 43; TL, time lapse (years) between PiB-PET imaging and autopsy.