Table 3.
Demographic data and volume fraction of cortical amyloid β (mean ± standard deviation) in FTD, age-matched control, and AD cases with amyloid β deposition and ≤75 years at death
| bvFTD | PPA | Age-matched controls | Age-matched AD | |
|---|---|---|---|---|
| Demographics | ||||
| N (% male) | 14 (79%) | 9 (33%) | 6 (66%) | 7 (71%) |
| Age at death (year) | 67 ± 5 | 70 ± 3 | 67 ± 8 | 69 ± 7 |
| Age at disease onset (year) | 62 ± 6 | 64 ± 5 | N/A | 62 ± 6 |
| Disease duration (year) | 6 ± 4 | 7 ± 4 | N/A | 5 ± 2 |
| Postmortem delay (hour) | 17 ± 14 | 21 ± 7 | 18 ± 9 | 22 ± 12 |
| Motor neuron disease [% (n)] | 14% (2/14) | 22% (2/9) | 0% (0/6) | 0% (0/7) |
| Extrapyramidal syndrome [% (n)] | 14% (2/14) | 22% (2/9) | 0% (0/6) | 0% (0/7) |
| C9ORF72 carrier [% (n)] | 14% (2/14) | 0% (0/9) | 0% (0/6) | 14% (1/7) |
| GRN carrier [% (n)] | 21% (3/14) | 0% (0/9) | 0% (0/6) | 14% (1/7) |
| MAPT carrier [% (n)] | 0% (0/14) | 0% (0/9) | 0% (0/6) | 0% (0/7) |
| Topographical distribution of Aβ | ||||
| A1/A2/A3 | 8/6/0 | 4/5/0 | 5/1/0 | 0/0/8 |
| Volume fraction of Aβ | ||||
| Frontal cortex | 2.6 ± 4.0∗ | 1.4 ± 1.2∗ | 1.5 ± 2.0∗ | 16.9 ± 10.0 |
| Temporal cortex | 3.5 ± 5.8∗ | 3.4 ± 3.4∗ | 0.6 ± 0.7∗ | 14.3 ± 6.7 |
| Frontotemporal cortices | 2.8 ± 4.2∗ | 2.2 ± 2.0∗ | 1.0 ± 1.3∗ | 15.6 ± 8.1 |
Abbreviations: bvFTD, behavioral variant frontotemporal dementia; PPA, primary progressive aphasia.
∗
P < .005 compared to AD.