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. 2017 Jun 16;12(6):e0179316. doi: 10.1371/journal.pone.0179316

Table 3. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) (95% confidence intervals) of dried blood spot (DBS) and dried plasma spot (DPS) compared with paired plasma specimen VL, patient support centers, Nyanza, Kenya.

(November 2012 to February 2013).

Plasma VL
CAP/CTM DBS VL Detectable Undetectable Total Sensitivity = 100.0 (97.6–100.0)
Specificity = 4.0 (0.5–13.7)
PPV = 75.8 (69.2–81.6)
NPV = 100.0 (15.8–100.0)
Detectable 150 48 198
Undetectable 0 2 2
Total 150 50 200
Abbott DBS VL Detectable Undetectable Total Sensitivity = 93.9 (88.8–97.2)
Specificity = 88.0 (82.2–92.4)
PPV = 100.0 (97.4–100.0)
NPV = 85.3 (73.8–93.0)
Detectable 137 0 137
Undetectable 11 52 63
Total 148 52 200
CAP/CTM DPS VL Detectable Undetectable Total Sensitivity = 94.7 (89.8–97.7)
Specificity = 94.0 (83.5–98.8)
PPV = 97.9 (94.1–99.6)
Detectable 142 3 145
Undetectable 8 47 55
Total 150 50 200
Abbott DPS VL Detectable Undetectable Total Sensitivity = 97.3 (93.2–99.2)
Specificity = 98.1 (89.7–100.0)
PPV = 99.3 (96.2–100.0)
NPV = 92.7 (82.4–98.0)
Detectable 142 1 143
Undetectable 6 51 57
Total 148 52 200

DBS viral load cut off of 400copies/mL and 550 copies/mL were used for CAP/CTM and Abbott respectively