Table 3. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) (95% confidence intervals) of dried blood spot (DBS) and dried plasma spot (DPS) compared with paired plasma specimen VL, patient support centers, Nyanza, Kenya.
Plasma VL | |||||
---|---|---|---|---|---|
CAP/CTM | DBS VL | Detectable | Undetectable | Total | Sensitivity = 100.0 (97.6–100.0) Specificity = 4.0 (0.5–13.7) PPV = 75.8 (69.2–81.6) NPV = 100.0 (15.8–100.0) |
Detectable | 150 | 48 | 198 | ||
Undetectable | 0 | 2 | 2 | ||
Total | 150 | 50 | 200 | ||
Abbott | DBS VL | Detectable | Undetectable | Total | Sensitivity = 93.9 (88.8–97.2) Specificity = 88.0 (82.2–92.4) PPV = 100.0 (97.4–100.0) NPV = 85.3 (73.8–93.0) |
Detectable | 137 | 0 | 137 | ||
Undetectable | 11 | 52 | 63 | ||
Total | 148 | 52 | 200 | ||
CAP/CTM | DPS VL | Detectable | Undetectable | Total | Sensitivity = 94.7 (89.8–97.7) Specificity = 94.0 (83.5–98.8) PPV = 97.9 (94.1–99.6) |
Detectable | 142 | 3 | 145 | ||
Undetectable | 8 | 47 | 55 | ||
Total | 150 | 50 | 200 | ||
Abbott | DPS VL | Detectable | Undetectable | Total | Sensitivity = 97.3 (93.2–99.2) Specificity = 98.1 (89.7–100.0) PPV = 99.3 (96.2–100.0) NPV = 92.7 (82.4–98.0) |
Detectable | 142 | 1 | 143 | ||
Undetectable | 6 | 51 | 57 | ||
Total | 148 | 52 | 200 |
DBS viral load cut off of 400copies/mL and 550 copies/mL were used for CAP/CTM and Abbott respectively