TABLE 1.
IC50s for growth inhibition of the pfmdrI transfectants by verapamil
| Transfectant | Pgh1 haplotype at codon:
|
IC50a (μM) | ||||
|---|---|---|---|---|---|---|
| 86 | 184 | 1034 | 1042 | 1246 | ||
| D10-mdrD10 | N | Y | S | N | D | 28.2 ± 3.8 |
| D10-mdr7G8/1 | N | Y | S | N | Y | 13.1 ± 1.3b |
| D10-mdr7G8/3 | N | Y | C | D | Y | 20.3 ± 3.1b |
| 7G8-mdr7G8 | N | F | C | D | Y | 7.7 ± 0.8 |
| 7G8-mdrD10 | N | F | S | N | D | 26.6 ± 4.1b |
a
Values are the means (± standard errors of the means) of results from six independent experiments, each carried out in either duplicate or triplicate.
b
Changes in IC50 relative to the parental control transfectant were significant as assessed with Student's t test (P < 0.05).