Table 1. The main GS PilA peptides investigated*.
Peptide | Sequence | Position in GS PilA | Assemblies |
---|---|---|---|
20-mer | FTLIELLIPQFSUYRVKUYN† | 1-8,22 (α1-N), 23-33 (α1-C) | Nanofibres |
12-mer | PQFSUYRVKUYN†,‡ | 22 (α1-N), 23-33 (α1-C) | None |
11-mer | QFSUYRVKUYN†,‡ | 23-33 (α1-C) | None |
9-mer | FTLIELLIP | 1-8,22 (α1-N) | Nanofibres |
8-mer | FTLIELLI | 1-8 (α1-N) | Nanofibres |
5-mer | FTLIE | 1-5 (α1-N) | Microcrystals |
4-mer | FTLI | 1-4 (α1-N) | Nanofibres, Nanoribbons |
*All peptides are C-terminally amidated in accordance with their positions in GS PilA.
†U denotes α-aminoisobutyric acid (Aib).
‡The peptide is N-terminally acetylated in accordance with its position in GS PilA.