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. 2017 Jun 6;12:4299–4322. doi: 10.2147/IJN.S136766

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© 2017 Shen et al. This work is published and licensed by Dove Medical Press Limited

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Schematic illustration of the synthesis procedure of LDM-PLGA/PPF/VEGF shRNA nanocomposites for codelivery of DOX and VEGF shRNA in EMT-6 tumor models.

Notes: (A) The preparation process of PEI-PEG-FA. (B) The construction of PLGA-based polymeric nanoparticles using a double emulsion solvent evaporation method. (C) The transport process of LDM-PLGA/PPF/VEGF shRNA nanocomposites and inhibition of tumor growth through cellular uptake via endocytosis, endosomal escape, intracellular VEGF shRNA, and DOX release.

Abbreviations: DOX, doxorubicin; PLGA, poly(d,l-lactic-co-glycolic acid); PEI-PEG-FA, polyethyleneimine premodified with polyethylene glycol-folic acid; PPF, PEI-PEG-FA; shRNA, small hairpin RNA; VEGF, vascular endothelial growth factor; siRNA, small interfering RNA; QDs, quantum dots; EDC, N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride; NHS, N-hydroxysuccinimide.