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. 2017 Jun 6;12:4299–4322. doi: 10.2147/IJN.S136766

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© 2017 Shen et al. This work is published and licensed by Dove Medical Press Limited

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The fluorescence disparity between the samples demonstrated the dynamic interplay of magnetic targeting versus biological targeting via folate under different magnetic fields.

Notes: (A) Fluorescence microscopy images of LDM-PLGA/PPF nanoparticles treated with HeLa cells (a) without and (b) with preincubation with free FA (1.25 mM) before exposure to an external magnetic field for 8 h. (B) Fluorescence microscopy images of HeLa cells with or without preincubation with free FA (1.25 mM) before treatment with LDM-PLGA/PPF nanoparticles for 4 h. (C) The intracellular DOX was quantitatively detected by fluorescence spectrophotometry. *P<0.05 compared with the FA-treated group.

Abbreviations: DOX, doxorubicin; FA, folic acid; PLGA, poly(d,l-lactic-co-glycolic acid); PPF, PEI-PEG-FA; PEI-PEG-FA, polyethyleneimine premodified with polyethylene glycol-folic acid.