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. 2017 Jun 6;12:4299–4322. doi: 10.2147/IJN.S136766

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© 2017 Shen et al. This work is published and licensed by Dove Medical Press Limited

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T₂-weighted MR images and quantitative signal intensity analysis of LDM-PLGA/PPF.

Notes: (A) T₂-weighted MR images and color T₂-weighted MR images of HeLa cells treated with LDM-PLGA/PPF at nanoparticle concentrations of 80, 100, 150, 200, and 300 μg/mL (or Fe concentrations of 1.8, 2.3, 3.4, 4.6, and 6.8 μg/mL) for 12 h. The color bar change from red to blue indicates the gradual decrease of MR signal intensity. (B) Quantitative signal intensity analysis. (C) In vivo T₂-weighted MR images of EMT-6 tumor-bearing mice before (left) and after (right) injection of LDM-PLGA/PPF. Tumors are marked by the red circle.

Abbreviations: MR, magnetic resonance; PLGA, poly(d,l-lactic-co-glycolic acid); PPF, PEI-PEG-FA; PEI-PEG-FA, polyethyleneimine premodified with polyethylene glycol-folic acid.