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. 2017 Jun 2;12:4195–4208. doi: 10.2147/IJN.S132190

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© 2017 Song et al. This work is published and licensed by Dove Medical Press Limited

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Ultrastructure and immunohistochemistry of the regenerated nerve 4 weeks posttreatment.

Notes: (A1–A4) Histology images by micrographs, scale bar: 2 μm. (B1–B4) Histology images stained with methylene blue, scale bar: 50 μm. (C1–C4) MBP immunohistochemistry of regenerated nerves. The brown spots indicated MBP-positive area, scale bar: 20 μm (A1–C1, miR-221/222⁻ group; A2–C2, the blank group; A3–C3, NC group; A4–C4, miR-221/222⁺ group). (D) Thickness of myelin sheath. (E) Density of myelinated nerve fibers (/10,000 μm²). (F) MBP-positive area (n=6 in each group. ^βP<0.05, ^ββP<0.01 the blank group versus miR-221/222⁻ group; ^δP<0.05, ^δδP<0.01 the NC group versus miR-221/222⁻ group; ^#P<0.05, ^##P<0.01 miR-221/222⁺ group versus the blank group; ^ϕP<0.05, ^ϕϕP<0.01, miR-221/222⁺ group versus the NC group; **P<0.01, ***P<0.001, miR-221/222⁺ group versus miR-221/222⁻ group).

Abbreviations: MBP, myelin basic protein; TEM, transmission electron microscope.

Ultrastructure and immunohistochemistry of the regenerated nerve 4 weeks posttreatment.

Notes: (A1–A4) Histology images by micrographs, scale bar: 2 μm. (B1–B4) Histology images stained with methylene blue, scale bar: 50 μm. (C1–C4) MBP immunohistochemistry of regenerated nerves. The brown spots indicated MBP-positive area, scale bar: 20 μm (A1–C1, miR-221/222⁻ group; A2–C2, the blank group; A3–C3, NC group; A4–C4, miR-221/222⁺ group). (D) Thickness of myelin sheath. (E) Density of myelinated nerve fibers (/10,000 μm²). (F) MBP-positive area (n=6 in each group. ^βP<0.05, ^ββP<0.01 the blank group versus miR-221/222⁻ group; ^δP<0.05, ^δδP<0.01 the NC group versus miR-221/222⁻ group; ^#P<0.05, ^##P<0.01 miR-221/222⁺ group versus the blank group; ^ϕP<0.05, ^ϕϕP<0.01, miR-221/222⁺ group versus the NC group; **P<0.01, ***P<0.001, miR-221/222⁺ group versus miR-221/222⁻ group).

Abbreviations: MBP, myelin basic protein; TEM, transmission electron microscope.