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. 2017 Jun 2;12:4195–4208. doi: 10.2147/IJN.S132190

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© 2017 Song et al. This work is published and licensed by Dove Medical Press Limited

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Toxicity to main organs and local muscle tissue in vivo.

Notes: Measured by frozen section after systemic injection of saline, naked siRNA and complexes at a N/P ratio of 300 (A1–C1, the saline control group; A2–C2, the naked miR-221/222 group; A3–C3, the PDAPEI/miR-221/222 group; A1–A3, local right thigh muscle; B1–B3, liver; C1–C3, kidney. Scale bar, 100 μm; H&E staining, ×200).

Abbreviations: H&E, hematoxylin and eosin; PDAPEI, PEI (1.8 kDa, branched) derivative with 2,6-pyridinedicarboxaldehyde (PDA) linkage; PEI, polyethylenimine; si RNA, short interfering RNA.