Panels (A), (B), (C), (D), (E), and (F) plot the power for association under binary trait models 1a, 1b, 2a, 2b, 3a, and 3b, respectively (described in the text and in supplementary Table S1). “Unrelated” denotes the Maximally-Unrelated strategy, “GIGI” denotes GIGI-Pick, “Re-Bal” denotes the Rebalanced Founder strategy, “Enrich” denotes the Enrichment strategy, and “G-STGY” denotes G-STRATEGY. Each of the five selection methods is implemented to select n = 300 individuals to be genotyped from among the 960 individuals in the sample. Empirical power for each model is based on 1,000 replicates with analysis performed using MQLS. Standard errors are given in parentheses.