Table 2.
Quantitative PET data of 64Cu-NOTA-heterodimer-ZW800 tracer uptakes after TF or CD105 blocking in BxPC-3-bearing nude mice
| Blocking group | Tissue | Time post-injection of the tracer | ||
|---|---|---|---|---|
|
| ||||
| 3 h | 12 h | 24 h | ||
| TF blocking (n=3) | BxPC-3 | 4.9 ± 1.5 | 5.2 ± 0.8 | 5.5 ± 1.1 |
| Blood | 11.0 ± 1.5 | 4.8 ± 0.6 | 3.4 ± 0.4 | |
| Liver | 14.4 ± 1.5 | 12.0 ± 1.2 | 12.0 ± 1.6 | |
| Kidney | 12.4 ± 1.5 | 13.0 ± 2.0 | 10.1 ± 0.8 | |
| Muscle | 1.1 ± 0.1 | 1.0 ± 0.1 | 1.0 ± 0.2 | |
|
| ||||
| CD105 blocking (n=3) | BxPC-3 | 6.5 ± 2.7 | 10.5 ± 1.5 | 10.8 ± 0.7 |
| Blood | 10.9 ± 0.6 | 5.2 ± 0.5 | 4.4 ± 0.3 | |
| Liver | 13.4 ± 1.9 | 11.5 ± 0.4 | 10.9 ± 0.9 | |
| Kidney | 12.8 ± 0.6 | 13.1 ± 1.9 | 10.7 ± 0.5 | |
| Muscle | 1.4 ± 0.2 | 1.0 ± 0.2 | 0.9 ± 0.2 | |
Values are reported as %ID/g (mean ± SD)