TABLE 1.
Characteristics of the S. enterica serovar Schwarzengrund strains studied
| Serovar | Strain | Origina | Year of isolation | Antibiotic resistance profileb | MICs quinolones (μg/ml)b
|
Substitutions in QRDRc
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NAL | FLU | ENR | MAR | CIP | GyrA | ParC | ParE | |||||
| Schwarzengrund | CGST2 | T | 2000 | Ap Cm Sm Sp Su Tc Tm | >1,024 [512] | >1,024 [64] | 256 [4] | 32 [4] | 64 [16] | Ser83Phe; Asp87Gly | Thr57Ser, Ser80Arg | Ser458Pro |
| Schwarzengrund | CGST3 | T | 2000 | Ap Cm Sm Sp Su Tc Tm | >1,024 [512] | 1,024 [64] | 64 [4] | 16 [4] | 16 [8] | Ser83Phe; Asp87Asn | Thr57Ser; Glu84Lys | |
| Schwarzengrund | CGST4 | T | 2001 | Ap Cm Sm Sp Su Tc Tm | >1,024 [512] | >1,024 [64] | 256 [4] | 32 [4] | 64 [16] | Ser83Phe; Asp87Gly | Thr57Ser; Ser80Arg | Ser458Pro |
| Schwarzengrund | CGST5 | T | 2002 | >1,024 [512] | >1,024 [128] | 64 [4] | 16 [2] | 16 [4] | Ser83Phe; Asp87Gly | Thr57Ser; Ser80Arg | ||
| Controls Schwarzengrund | 383SA99 | B | 1999 | 4 | 1 | 0.060 | 0.030 | 0.030 | Thr57Ser | |||
| Hadar | 13SA02 | B | 2002 | 4 | 1 | 0.125 | 0.060 | 0.030 | Thr57Ser | |||
| Typhimurium | S/921495 | S | 1992 | 4 | 0.5 | 0.125 | 0.060 | 0.030 | ||||
a
T, Taiwan; B, Belgium; S, Scotland.
b
Antibiotics are ampicillin (Ap), chloramphenicol (Cm), streptomycin (Sm), spectinomycin (Sp), sulfonamide (Su), tetracycline (Tc), trimethoprim (Tm), nalidixic acid (NAL), flumequine (FLU), enrofloxacin (ENR), marbofloxacin (MAR), and ciprofloxacin (CIP). Numbers in brackets are the MICs in the presence of PABN at 80 μg/ml.
c
No GyrB substitutions were detected.