Figure 1.

SMR Analysis Using mQTLs and eQTLs Implicates a Role for RNASET2 in Crohn Disease

Shown is a chromosome 6 genomic region (UCSC Genome Browser hg19: 167,243,095–167,565,882) identified in a recent Crohn disease GWAS performed by Liu et al.⁵ Genes located in this region are shown at the top; exons are indicated by thicker bars, and red arrows indicate the direction of transcription. DNA methylation sites interrogated by the Illumina 450K array are indicated by solid vertical lines underneath the genes. The four bottom panels depict the −log₁₀ p value (y axis) against genomic location (x axis) from (A) SMR analysis (black squares represent Illumina 450K array DNA methylation sites, blue triangles represent gene expression probes, and green and red coloring highlight those with a non-significant HEIDI test for DNA methylation and gene expression, respectively), (B) blood mQTL (n = 639) results for the DNA methylation site cg25258033 (outlined in black in A), (C) blood eQTL (n = 5,311) results for ILMN1671565 (outlined in black in A), and (D) the Crohn disease GWAS performed by Liu et al.⁵