Figure 2.

SMR Analysis Using Whole-Blood and Fetal Brain mQTL Data Implicates a Role for HEY2 in Migraine

Shown is a chromosome 6 genomic region (UCSC Genome Browser hg19: 125,970,800–126,170,800) identified in a recent migraine GWAS performed by Gormley et al.²⁵ Genes located in this region are shown at the top; exons are indicated by thicker bars, and red arrows indicate the direction of transcription. The four bottom panels depict the −log₁₀ p value (y axis) against genomic location (x axis) from (A) SMR analysis (points represent DNA methylation sites interrogated by the Illumina 450K array, squares and diamonds indicate SMR tests from blood and fetal brain mQTLs, respectively, and green squares and blue diamonds highlight those with a non-significant HEIDI test for blood and fetal brain, respectively), mQTL results for the DNA methylation site cg05901451 (outlined in black in A) in (B) blood (n = 639) and (C) fetal brain (n = 166), and (D) the migraine GWAS performed by Gormley et al. (n = 59,674 case and 316,078 control samples).²⁵