Table 1. Identified and known functions of SLC25 family members that genetically interact with HEM25.

Standard Name	Systematic Name	Known Function(s)
FLX1	YIL134w	Mitochondrial flavin adenine dinucleotide transporter; FAD is a synthesis product of riboflavin; human homolog SLC25A32 is implicated in multiple acyl-CoA dehydrogenase deficiency (MADD) or glutaric aciduria type II (GAII), and can complement yeast null mutant
MTM1	YGR257c	Mitochondrial protein of the mitochondrial carrier family; high affinity pyridoxal 5′-phosphate (PLP) transporter, important for delivery of PLP cofactor to mitochondrial enzymes; involved in mitochondrial iron homeostasis
ORT1	YOR130c	Ornithine transporter of the mitochondrial inner membrane; exports ornithine from mitochondria as part of arginine biosynthesis; functionally complemented by human ortholog, SLC25A15, which is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome, but HHH-associated variants fail to complement
SFC1	YJR095w	Mitochondrial succinate-fumarate transporter; transports succinate into and fumarate out of mitochondria; required for ethanol and acetate utilization
PET8	YNL003c	S-adenosylmethionine transporter of the mitochondrial inner membrane; member of the mitochondrial carrier family; required for biotin biosynthesis and respiratory growth
AAC3	YBR085w	Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; has roles in maintenance of viability and in respiration