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. 2017 Jun 16;7:3756. doi: 10.1038/s41598-017-03998-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Kinetics in the heart, skeleton, kidneys and elimination. Representative time-activity curves of the [⁶⁴Cu]Cu-NOTA-HsTX1[R14A] in PET studies (a) heart, skeleton and (b) kidneys of rats after single i.v. (n = 1) or subcutaneous s.c. injection (n = 1). Biodistribution data of the (c) elimination of the activity from the body after single i.v. (8 animals; mean ± SEM) or s.c. (4 animals; mean ± SEM) injection and (d) renal and hepatobiliary elimination of the [⁶⁴Cu]Cu-NOTA-HsTX1[R14A] after single i.v. or s.c. injection.