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. 2017 Jun 16;7:3692. doi: 10.1038/s41598-017-03630-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Nuclear distribution of host chromatin in infected cells with enlarged VRCs. (A) Confocal microscopy images showing the distribution of DAPI-labelled chromatin (cyan) and lamin B (green) together with maximum intensity projections (MIP) of viral EYFP-ICP4 (yellow) and VP5 (magenta) proteins at 24 h p.i. A differential interference contrast (DIC) image is also shown. Scale bar, 3 µm. (B) The mean spatial distribution of chromatin in infected (n = 16) and non-infected (n = 20) cells together with VP5 and ICP4 shown as plots of the intensity at increasing distances from the NE. Dotted error lines represent the mean ± the standard error of the mean (SEM). (C) A TEM image of an infected cell nucleus at 24 h p.i. The inset shows an enlarged view of the boxed area containing the viral capsid in the space between the inner and outer leaflets of the nuclear membrane. Scale bar, 3 µm.