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. 2017 Jun 16;7:3741. doi: 10.1038/s41598-017-03447-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of cell-permeable TAT-4BB decoy peptide on thermal sensitivity and tactile allodynia. (A) TAT-4BB and TAT-CP was tested for the ability to alter nocifensive behavior in naïve rats. (B) TAT-4BB was tested for the ability to prevent sensitivity to tactile stimulus one hour after M3G administration. TAT-4BB potently affected behavioral hypersensitivity at 10 mg/kg but not 1 mg/kg. Values are the mean ± SEM of two groups of 8 rats per time point. (∗ = p < 0.05 TAT-4BB in combination with M3G rats compared to M3G treatment alone).