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. 2017 Jun 16;7:3753. doi: 10.1038/s41598-017-03573-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ADAMTS-7 is increased in symptomatic and vulnerable lesions. ADAMTS-7 (% of plaque area stained) is increased in carotid lesions removed by endarterectomy from symptomatic patients compared to lesions from asymptomatic patients (a). ADAMTS-7 is increased in lesions with a high vulnerability index (above median) (b). Vulnerability index was calculated based on lipid-, CD68-, hemorrhage-, SMC-, and collagen-staining (% of plaque areas stained). Values are presented as boxplots. Number of plaques = 206; Mann-Whitney test.