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. 2017 Jun 16;7:3734. doi: 10.1038/s41598-017-03997-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Macroscopic (A), electronmicroscopical (B) and histological analysis (C) of a harbor seal infected with seal parapoxvirus. (A) Ulcerative nodular skin lesion were identified on both front fins and the muzzle of the animal. (B) Histological changes of hair follicle epithelium characterized by ballooning degeneration and cytoplasmic eosinophilic inclusion bodies (arrows), magnification 600x. Normal hair follicle epithelium of an unaffected grey seal is shown in the upper right corner, HE, magnification 600x. (C) Electron microscopy pictures of the cytoplasm of a hair follicle epithelial cell isolated from an infected seal skin lesion. Magnification 37,500x. Mature and immature virus like particles were densely packed. The ovoid to lancealate shape of the core virions are clearly visible. (D) In situ hybridization using a digoxigenin-labeled parapoxvirus-specific DNA probe: parapox virus specific signal is detected in hair follicle epithelial cells of the suprabasal layers (arrow), while no specific signal was detected in the basal layers. Left panel represents an overview with a 100 x magnification, right panel shows a blown up of the highlighted area, magnification: 200x.