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. 2017 Jun 16;7:3677. doi: 10.1038/s41598-017-04033-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Optofluidic results for blood samples, and computerised tomography of cancer patients at the time of blood extraction. (A) 3 healthy donors and (B) 5 cancer patients. (C) Computerised tomography scans of the cancer patients at the time of blood extraction. CP1, lung metastasis (red arrow). CP2, bone scintigraphy and MRI before (showing a lytic metastasis in C6) and at the time of blood extraction (complete remission). CP3, recently diagnosed and untreated yet metastatic adenopathy (red arrow). CP4, vertebral osteoblastic metastasis showing the current bone progression of the disease (red arrow). CP5, malignant pleural effusion (red arrow) and mediastinal mass (blue arrow). At the time of the study, CP5 had received four cycles of specific treatment. (D) Comparison of the results for the blood samples between the flow-cytometry and the optofluidic device.