Table 2.
Summary of hypoxia-regulated differentially expressed proteins (DEPs).
| Protein | TH/YH | TL/YL | TH/TL | YH/YL | Functional analysis |
|---|---|---|---|---|---|
| MYL7 | 2.05 | 0.79 | 1.60 | 0.62 | muscle contraction, actin cytoskeleton, actin binding, ATPase activity, contractile fiber part |
| PTPMT1 | 1.46 | 0.67 | 1.80 | 0.83 | mitochondrion, inflammatory response, acute inflammatory response |
| PDLIM3 | 1.60 | 1.21 | 1.34 | 1.02 | heart development, actin cytoskeleton, contractile fiber, cardiovascular development |
| A2M | 1.42 | 0.72 | 1.62 | 0.83 | Complement and coagulation cascades, blood microparticle, inflammatory response, regulation of immune effector process, VEGF signaling pathway |
| C6 | 1.29 | 0.78 | 1.28 | 0.77 | inflammatory response, positive regulation of immune system process, acute inflammatory response, positive regulation of immune response, response mediated by circulating, defense response |
| CRYAB | 1.46 | 0.86 | 1.41 | 0.82 | response to hypoxia, mitochondrion, response to reactive oxygen species, oxygen and reactive oxygen species metabolic process, muscle contraction, oxygen species metabolic process |
| PDK4 | 1.10 | 1.02 | 1.45 | 1.34 | mitochondrion, ATP binding, mitochondrion, reactive oxygen species metabolic process, glucose metabolic process |
| ERK2 | 1.20 | 0.98 | 1.15 | 0.94 | HIF-1 signaling pathway, mTOR signaling pathway, TGF-beta signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, cardiac muscle contraction |
| ACE | 1.25 | 0.77 | 1.30 | 0.80 | Vasculature development, response to oxygen levels, response to hypoxia, immune system development, regulation of blood pressure, heart contraction, Renin-angiotensin system, blood circulation |
| NAPG | 1.24 | 0.77 | 1.21 | 0.75 | mitochondrion, inflammatory response, actin filament binding, |
| CPS1 | 1.22 | 0.44 | 1.49 | 0.54 | mitochondrion, glucose metabolic process, oxidation of organic compounds |
| HSPE1 | 0.98 | 1.50 | 0.80 | 1.23 | inflammatory response, mitochondrion |
| DECR1 | 0.95 | 1.59 | 0.81 | 1.35 | mitochondrion, 2, 4-dienoyl-CoA reductase (NADPH) activity, NADPH binding, oxidation reduction, iron ion homeostasis, muscle contraction |
| AHSG | 0.72 | 1.20 | 0.78 | 1.30 | inflammatory response, defense response, |
| ENO3 | 0.76 | 1.20 | 0.65 | 1.03 | HIF-1 signaling pathway, glycolysis/gluconeogenesis, glucose metabolic process |
| MRPS26 | 0.63 | 1.40 | 0.68 | 1.52 | mitochondrion, ribosome |
| DCN | 0.50 | 0.80 | 0.80 | 1.29 | TGF-beta signaling pathway |
| COL3A1 | 0.41 | 0.70 | 0.83 | 1.41 | response to radiation, blood vessel development, Platelet activation |
| COL1A2 | 0.40 | 0.80 | 0.83 | 1.65 | blood circulation, regulation of blood pressure, small GTPase mediated signal transduction |
| KRT8 | 0.32 | 0.67 | 0.75 | 1.56 | contractile fiber part |
TH, Tibetan highland pig; TL, Tibetan lowland pig; YH, Yorkshire highland pig; YL, Yorkshire lowland pig.