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Hydroxyurea dose escalation and toxicity criteria.
| Toxicity | Parameter | Escalation criteria | Dose-limiting toxicity |
| Neutropenia | ANCa (x109/L) | > 4.0 | <1.0 x 109/L |
| Anemia | Hemoglobin (gm/dL) | > 6.5 | Hbb <7.5 gm/dL unless ARCc >100 x 109/L |
| Reticulocytopenia | ARC (x109/L) | > 150 | ARC <80 x 109/L unless Hb >8.5 gm/dL |
| Thrombocytopenia | Platelets (x109/L) | > 150 | <80 x 109/L |
aANC: absolute neutrophil count.
bHb: hemoglobin.
cARC: absolute reticulocyte count.
