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A total of 2,787 samples sent for analysis of antinatalizumab antibodies (NAT-ab) were screened. Samples from 1,183 patients with a diagnosis of MS were evaluated for AQP4-IgG by a cell-based assay (CBA). Positive samples were retested with further CBAs and ELISAs. NMOSD was diagnosed according to the 2015 criteria. AQP4-ab = aquaporin-4 antibody; NMOSD = neuromyelitis optica spectrum disorder.
