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. 2017 Jun 16;21:158. doi: 10.1186/s13054-017-1743-9

Table 1.

Clinical description of the study cohort

Variable Hydrocortisone (n = 15) Placebo (n = 15) Total (n = 30) P value
Age, years 47 (42–50) 48 (36–59) 48 (39–55) 0.72
Gender, number of female patients (%) 2 (13%) 6 (40%) 8 (27%) 0.22
Weight (usual), kg 73 (68–86) 80 (65–93) 78 (65–86) 0.84
Weight at inclusion, kg 94 (77–98) 100 (77–112) 94 (77–104) 0.25
TBSA (%) 75 (54–87) 70 (44–76) 70 (48–84) 0.18
Baux score 117 (103–129) 109 (102–119) 110 (102–125) 0.29
ABSI score 12 (11–13) 11 (10–12) 11 (10–12) 0.06
Inhalation injury, n (%) 9 (60%) 3 (20%) 12 (40%) 0.06
Interval (burn injury-inclusion), h 57 (52–66) 46 (41–58) 54 (42–62) 0.11
Etomidate injection prior to inclusion, n (%) 5 (36%) 12 (80%) 17 (58%) 0.03
Blood transfusions before inclusion, n (%) 4 (27%) 3 (20%) 7 (23%) 1
Diuresis prior to inclusion (L/day) 3.2 (2.0–4.2) 3.5 (2.8–4.3) 3.4 (2.2–4.3) 0.47
Plasma creatinine prior to inclusion, μmol/L 86 (78–128) 88 (59–100) 87 (72–105) 0.28
Plasma protein prior to inclusion, g/L 42 (38–45) 41 (39–45) 42 (38–46) 1
Hemoglobin prior to inclusion, g/L 106 (100–117) 113 (90–132) 110 (94–123) 0.72
White blood cells prior to inclusion, 109/L 5.0 (3.2–7.4) 6.6 (3.5–11.5) 5.3 (3.1–9.6) 0.25
Lymphocytes prior to inclusion, 109/L 0.9 (0.6–1.1) 1.1 (0.8–1.4) 0.9 (0.7–1.3) 0.14
Basal cortisol, µg/dL 15.2 (8.8–21.8) 13.8 (8.4–19.1) 14.5 (8.3–19.9) 0.77
Norepinephrine prior to inclusion, μg/kg/min 0.59 (0.53–0.66) 0.60 (0.51–1.04) 0.60 (0.51–0.78) 0.55
Duration of norepinephrine protocol, h 60 (42–117) 120 (84–141) 102 (56–131) 0.05
Total quantity of norepinephrine over ICU stay, μg/kg 1457 (1132–3705) 1971 (1535–3893) 1771 (1196–4068) 0.27
Septic shock, n (%) 5 (33%) 7 (47%) 12 (40%) 0.71
Number of infections 1 (1–3) 2 (2–3) 2 (1–3) 0.1
Number of skin grafts 4 (1–7) 5 (4–10) 5.00 (1.3–8.5) 0.13
Duration of hospitalization, days 65 (11–77) 67 (51–104) 66 (22–89) 0.11
Deaths before 28 days, n (%) 6 (40%) 2 (13%) 8 (27%) 0.22

TBSA total burn surface area, ABSI Abbreviated Burn Severity Index