Table 1.
Variable | Hydrocortisone (n = 15) | Placebo (n = 15) | Total (n = 30) | P value |
---|---|---|---|---|
Age, years | 47 (42–50) | 48 (36–59) | 48 (39–55) | 0.72 |
Gender, number of female patients (%) | 2 (13%) | 6 (40%) | 8 (27%) | 0.22 |
Weight (usual), kg | 73 (68–86) | 80 (65–93) | 78 (65–86) | 0.84 |
Weight at inclusion, kg | 94 (77–98) | 100 (77–112) | 94 (77–104) | 0.25 |
TBSA (%) | 75 (54–87) | 70 (44–76) | 70 (48–84) | 0.18 |
Baux score | 117 (103–129) | 109 (102–119) | 110 (102–125) | 0.29 |
ABSI score | 12 (11–13) | 11 (10–12) | 11 (10–12) | 0.06 |
Inhalation injury, n (%) | 9 (60%) | 3 (20%) | 12 (40%) | 0.06 |
Interval (burn injury-inclusion), h | 57 (52–66) | 46 (41–58) | 54 (42–62) | 0.11 |
Etomidate injection prior to inclusion, n (%) | 5 (36%) | 12 (80%) | 17 (58%) | 0.03 |
Blood transfusions before inclusion, n (%) | 4 (27%) | 3 (20%) | 7 (23%) | 1 |
Diuresis prior to inclusion (L/day) | 3.2 (2.0–4.2) | 3.5 (2.8–4.3) | 3.4 (2.2–4.3) | 0.47 |
Plasma creatinine prior to inclusion, μmol/L | 86 (78–128) | 88 (59–100) | 87 (72–105) | 0.28 |
Plasma protein prior to inclusion, g/L | 42 (38–45) | 41 (39–45) | 42 (38–46) | 1 |
Hemoglobin prior to inclusion, g/L | 106 (100–117) | 113 (90–132) | 110 (94–123) | 0.72 |
White blood cells prior to inclusion, 109/L | 5.0 (3.2–7.4) | 6.6 (3.5–11.5) | 5.3 (3.1–9.6) | 0.25 |
Lymphocytes prior to inclusion, 109/L | 0.9 (0.6–1.1) | 1.1 (0.8–1.4) | 0.9 (0.7–1.3) | 0.14 |
Basal cortisol, µg/dL | 15.2 (8.8–21.8) | 13.8 (8.4–19.1) | 14.5 (8.3–19.9) | 0.77 |
Norepinephrine prior to inclusion, μg/kg/min | 0.59 (0.53–0.66) | 0.60 (0.51–1.04) | 0.60 (0.51–0.78) | 0.55 |
Duration of norepinephrine protocol, h | 60 (42–117) | 120 (84–141) | 102 (56–131) | 0.05 |
Total quantity of norepinephrine over ICU stay, μg/kg | 1457 (1132–3705) | 1971 (1535–3893) | 1771 (1196–4068) | 0.27 |
Septic shock, n (%) | 5 (33%) | 7 (47%) | 12 (40%) | 0.71 |
Number of infections | 1 (1–3) | 2 (2–3) | 2 (1–3) | 0.1 |
Number of skin grafts | 4 (1–7) | 5 (4–10) | 5.00 (1.3–8.5) | 0.13 |
Duration of hospitalization, days | 65 (11–77) | 67 (51–104) | 66 (22–89) | 0.11 |
Deaths before 28 days, n (%) | 6 (40%) | 2 (13%) | 8 (27%) | 0.22 |
TBSA total burn surface area, ABSI Abbreviated Burn Severity Index