Table 1.
Differential expression of miR-200 and miR-205 in ovarian and fallopian tube cells
| Ovarian cells | Fallopian tube cells | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| MicroRNA | Overall P-value |
BNT | BOT | NSMT | SMT | CCL | Ov_ST | Overall p-value | STIC | FT_ST |
| Difference in medians against normal cells (P-value) | Difference in medians against normal cells (P-value) | |||||||||
| MiR-200a | <0.0005† | 1.807 (1.000) | 2.839 (0.003*) | 3.206 (0.001*) | 3.081 (0.001*) | 2.440 (0.002*) | −1.612 (0.672) | 0.018† | 2.613 (0.114) | −1.227 (0.114) |
| MiR-200b | <0.0005† | −0.160 (1.000) | 2.537 (0.006*) | 2.544 (0.001*) | 3.060 (0.001*) | 4.051 (0.001*) | −2.797 (0.396) | 0.050† | 2.970 (0.114) | −0.572 (1.000) |
| MiR-200c | <0.0005† | 2.280 (0.060) | 4.231 (0.004*) | 4.516 (0.001*) | 5.729 (0.001*) | 5.919 (0.006*) | −1.120 (1.000) | 0.055 | 4.331 (0.114) | 0.450 (1.000) |
| MiR-141 | <0.0005† | 2.315 (0.030*) | 3.978 (0.003*) | 4.335 (0.001*) | 4.412 (0.001*) | 2.738 (0.001*) | −1.310 (1.000) | 0.034† | 4.883 (0.114) | 1.702 (0.458) |
| MiR-429 | <0.0005† | 1.241 (1.000) | 2.295 (0.005*) | 2.825 (0.001*) | 2.090 (0.004*) | 1.664 (0.004*) | −2.897 (0.270) | 0.047† | 5.204 (0.114) | 2.370 (1.000) |
| MiR-205 | 0.001† | −1.622 (1.000) | 5.396 (0.792) | 0.912 (1.000) | 2.725 (0.030*) | 8.156 (0.002*) | −1.664 (1.000) | 0.021† | 4.861 (0.114) | 0.280 (0.458) |
BNT Benign tumors, BOT Borderline tumors, NSMT Non-Serous malignant tumors, SMT Serous malignant tumors, CCL Cancer cell lines, Ov_ST Ovarian stroma, STIC Serous tubal intraepithelial carcinoma, FT_ST Fallopian tube stroma
†significant at the 0.05 level by Kruskal Wallis test
*significant at the 0.05 level by Mann-Whitney test (corrected using the Bonferroni method for multiple comparisons)