Table 3.
Network characteristics by tumor location
| Total (N = 1380) | Proximal colon cancer (N = 690) | Distal colorectal cancer (N = 690) | |
|---|---|---|---|
| Correlation network based on original variables | |||
| Number of nodes | 54 | 54 | 54 |
| Number of edges | 268 | 173 | 95 |
| Median degree | 8.0 | 3.0 | 2.0 |
| Average clustering coefficient | 0.52 | 0.50 | 0.30 |
| Hubsa (degree centrality) |
RUNX3 (0.47) CACNA1G (0.45) MSI (0.45) MLH1 (0.43) TIL (0.43) BRAF (0.40) NEUROG1 (0.40) CRABP1 (0.38) IGF2 (0.38) SOCS1 (0.38) CDKN2A b (0.36) MIR155 (0.36) |
MSI (0.39) MLH1 (0.36) |
- |
| Correlation network in non-MSI-high cancer | |||
| Number of nodes | 53 | 53 | 53 |
| Median degree | 4.0 | 1.0 | 1.0 |
| Number of edges | 120 | 64 | 56 |
| Average clustering coefficient | 0.33 | 0.23 | 0.26 |
| Hubsa (degree centrality) |
RUNX3 (0.15) NEUROG1 (0.15) |
BRAF (0.19) CDKN2A b (0.17) IGF2 (0.17) RUNX3 (0.17) CACNA1G (0.15) CRABP1 (0.15) NEUROG1 (0.15) |
RUNX3 (0.15) NEUROG1 (0.15) |
| Correlation network based on the same number of edges | |||
| Number of nodes | 54 | 54 | 54 |
| Median degree | 1.5 | 4.0 | 1.0 |
| Number of edges | 100 | 100 | 100 |
| Average clustering coefficient | 0.27 | 0.29 | 0.27 |
| Hubsa (degree centrality) |
CACNA1G (0.26) IGF2 (0.26) RUNX3 (0.25) BRAF (0.23) MLH1 (0.23) MSI (0.23) CRABP1 (0.21) TIL (0.21) CDKN2A b (0.19) NEUROG1 (0.19) SOCS1 (0.19) |
CACNA1G (0.28) MLH1 (0.26) MSI (0.26) IGF2 (0.25) RUNX3 (0.25) BRAF (0.23) CRABP1 (0.23) CDKN2A b (0.21) TIL (0.21) NEUROG1 (0.19) SOCS1 (0.17) |
RUNX3 (0.19) IGF2 (0.17) NEUROG1 (0.17) |
aMarkers with degree centrality at or above the 80th percentile in the colorectal cancer network
b CDKN2A promoter hypermethylation
MSI microsatellite instability, TIL Tumor infiltrating lymphocytes