Table 4.

Drug interactions with gemfibrozil

Concomitant medication	Cautions
HMG-CoA Reductase Inhibitors	risk of myopathy and rhabdomyolysis
Anticoagulants	warfarin dosage should be reduced
CYP2C8 Substrates	drugs metabolized CYP2C8 (e.g., dabrafenib, loperamide, montelukast, paclitaxel, pioglitazone, rosiglitazone) may be required to reduce
OATP1B1 substrates	substrates of OATP1B1 (e.g., atrasentan, atorvastatin, bosentan, ezetimibe, fluvastatin, glyburide, SN-38 [active metabolite of irinotecan], rosuvastatin, pitavastatin, pravastatin, rifampin, valsartan, olmesartan) may be required to reduce
Bile Acid-Binding Resins	resin-granule drugs such as colestipol (5 g) are recommended at 2 or more hours apart
Colchicine	myopathy, including rhabdomyolysis in chronic administration of colchicine

SPC of LOPID issued March.2016