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. 2017 Jun 17;17:159. doi: 10.1186/s12872-017-0585-3

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — a, b and c Show the mean methylation status of each CG pairs in the promoter region of ICAM-1 gene in healthy control, NYHA IIgroup and NYHA III group respectively). Compared with healthy control, the promoter region methylation status with 20 CG pairs (−2095, −2091, −2088, −2077, −2068, −2055,-2046, −2039, −2032, −2010, −2000, −1998, −1991, −1954, −1916, −1893, −1883, −1855, −1839 and -1793 bp) of ICAM-1 gene were gradually decreased in NYHA II and NYHA III group. d, the average methylation level of CpG pairs in the region (−2138 to -1759 bp) of ICAM-1 promoter is gradually decreased in NYHA IIand NYHA III group compared to healthy control. (^*, p < 0.05; ^**, p < 0.01)