Table 4.

Change from baseline for PANSS following 12 weeks of treatment

		Oxytocin			Placebo
Outcome Variablea	Time Point (wks)	N	LS Mean (SE)	P-Valueb Diff>0	N	LS Mean (SE)	P-Valueb Diff>0	P-Valuec Trt Diff
PANSS Total	2	32	−4.10 (1.35)	0.004	30	−6.13 (1.40)	0.000	0.310
	6	28	−3.23 (1.49)	0.035	29	−5.56 (1.49)	0.000	0.279
	9	27	−4.21 (1.69)	0.016	29	−4.77 (1.65)	0.006	0.815
	12	26	−3.54 (1.60)	0.032	29	−5.49 (1.54)	0.001	0.389
PANSS Positive	2	32	−1.21 (0.43)	0.007	30	−1.40 (0.45)	0.003	0.774
	6	28	−0.59 (0.55)	0.292	29	−1.68 (0.55)	0.003	0.168
	9	27	−1.39 (0.60)	0.025	29	−1.50 (0.59)	0.014	0.894
	12	26	−1.10 (0.56)	0.056	29	−1.49 (0.54)	0.008	0.614
PANSS Negative	2	32	−1.20 (0.52)	0.024	30	−0.65 (0.54)	0.232	0.467
	6	28	−1.28 (0.62)	0.044	29	−0.36 (0.62)	0.558	0.303
	9	27	−0.92 (0.55)	0.099	29	−0.13 (0.54)	0.816	0.309
	12	26	−1.18 (0.59)	0.051	29	−0.64 (0.57)	0.261	0.521
PANSS General	2	32	−1.76 (0.84)	0.042	30	−4.02 (0.88)	0.000	0.071
	6	28	−1.41 (0.79)	0.077	29	−3.46 (0.79)	0.000	0.076
	9	27	−1.92 (1.10)	0.087	29	−3.08 (1.08)	0.006	0.460
	12	26	−1.44 (0.93)	0.127	29	−3.28 (0.89)	0.001	0.164

Abbreviations: LS, least squares; PANSS, Positive and Negative Syndrome Scale

^aModels adjusted for baseline value and age in addition to treatment group.

^bTest for within-group change

^cTest for between-group change