Table 1.

Summary of select environmental HPV toxicants, shown together with how their adverse health concerns have been addressed with in vitro, animal, and human physiological response models. The most common health concerns of interest were those altering reproductive systems, altering developmental systems, inducing cancer, altering neurological systems, and inducing acute toxicity responses. Although there are statistical studies determining potential associations between existing adverse effects and human exposure of toxicants, those were not considered as human physiological response models.

Group	Representative Chemical and Its Structure	Half-life	In vitro or Animal Model Available to Address Adverse Health Concerns?	Human Physiological Response Model Available to Address Adverse Health Concerns?
Environmental phenols		4-5 hours [78]	Reproductive: Y Developmental: Y Cancer: Y Neurological: Y Acute: Y *All from [78]	Reproductive: Little Developmental: N Cancer: N Neurological: N Acute: N *All from [78]
PBDE		Average 15 days. Longer half-lives with decreasing bromides (37-91 days) [79]	Reproductive: Y [27] Developmental: Y [27] Cancer: Y [76] Neurological: Y [27] Acute: Y [18]	Reproductive: Y [29,81] Developmental: N Cancer: N Neurological: Y [29,82] Acute: N
Phthalates		12 hours [83]	Reproductive: Y [84] Developmental: Y [35,85] Cancer: Y [36] Neurological: N Acute: Y [36]	Reproductive: N Developmental: N Cancer: N Neurological: N Acute: N
PFCs		3.5 years [37,38]	Reproductive: Y [86] Developmental: Y [86,87] Cancer: Y [86] Neurological: Y [88] Acute: Y [89]	Reproductive: N Developmental: N Cancer: N Neurological: N Acute: N