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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Cancer. 2017 Mar 13;123(13):2535–2542. doi: 10.1002/cncr.30637

Table 2.

Body Mass Index at Diagnosis and Recurrence and Survival by PAM50 Subtype (n=1,559)

Breast Cancer-Specific Survival Recurrence
All women, adjusted Deaths1 HR2,3 95%CI Recurrences HR 95%CI
    18.5-<25-kg/m2 119 Reference 147 Reference
    25-<30-kg/m2 90 0.94 0.71 1.24 111 0.94 0.69 1.29
    30-<35-kg/m2 57 0.98 0.71 1.36 66 0.98 0.67 1.43
    ≥35-kg/m2 46 1.06 0.74 1.52 54 1.02 0.67 1.54
    Per 5-unit BMI 312 1.05 0.95 1.15 378 1.03 0.92 1.14
Luminal A
    18.5-<25-kg/m2 43 Reference 52 Reference
    25-<30-kg/m2 31 1.36 0.84 2.19 39 1.43 0.78 2.62
    30-<35-kg/m2 17 1.29 0.72 2.33 18 1.05 0.50 2.18
    ≥35-kg/m2 19 2.24 1.22 4.11 21 2.17 0.92 5.11
    Per 5-unit BMI 110 1.31 1.11 1.54 130 1.24 1.00 1.54
Luminal B
    18.5-<25-kg/m2 32 Reference 39 Reference
    25-<30-kg/m2 26 0.62 0.36 1.06 33 0.67 0.27 1.71
    30-<35-kg/m2 25 1.39 0.80 2.41 30 1.69 0.62 4.64
    ≥35-kg/m2 11 0.61 0.29 1.29 13 0.58 0.15 2.21
    Per 5-unit BMI 94 0.99 0.83 1.18 115 0.98 0.71 1.35
Basal-Like
    18.5-<25-kg/m2 17 Reference 18 Reference
    25-<30-kg/m2 18 1.23 0.63 2.43 20 1.18 0.55 2.57
    30-<35-kg/m2 8 0.52 0.22 1.26 10 0.72 0.14 3.68
    ≥35-kg/m2 9 0.67 0.28 1.59 11 0.75 0.25 2.25
    Per 5-unit BMI 52 0.90 0.73 1.11 59 0.93 0.74 1.17
Her2-Overexpressing
    18.5-<25-kg/m2 27 Reference 38 Reference
    25-<30-kg/m2 15 0.78 0.40 1.51 19 0.66 0.17 2.50
    30-<35-kg/m2 7 0.69 0.28 1.71 8 0.54 0.06 5.16
    ≥35-kg/m2 7 0.89 0.37 2.15 9 0.79 0.21 2.99
    Per 5-unit BMI 56 0.92 0.71 1.20 74 0.87 0.53 1.41
1

Number of events is unweighted.

2

Hazard ratios and confidence intervals are weighted to account for stratified case-cohort study design with strata defined as IHC clinical subtype.

3

Adjusted for for age, menopausal status, race/ethnicity, study, stage and receipt of any chemotherapy.