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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Bone. 2017 Jan 20;100:41–49. doi: 10.1016/j.bone.2017.01.017

Table 1.

Potential applications of circulating Klotho in clinical nephrology

Biomarker Therapeutic agent
Diagnostic

  • Prediction of early onset CKD

 Prophylactic

  • Prevention of post-AKI CKD development in high risk groups

  • Prevention of CVD development in CKD patients
Prognostic

  • Prediction of CKD progression

  • Prediction of ESRD development

  • Prediction of CVD

 Therapeutic

  • Ameliorates hyperphosphatemia toxicity

  • Ameliorates CKD-MBD

  • Attenuates CVD

AKI: acute kidney injury; CKD: chronic kidney disease; CKD-MBD: chronic kidney disease-mineral and bone disorder; CVD: cardiovascular disease; ESRD: end-stage renal disease